08/Eyl/2021
In individuals administered the Pfizer-BioNTech vaccine, the individual’s own body cells produce part of the virus. This part of the virus, which is produced in abundance in the body, is considered as a foreign substance by the body, although it is produced in the person’s own body. The body takes action to protect itself against these foreign substances and creates immunity. This immunity is against an important part of the virus because the virus can enter human cells with this part. With this immunity, the virus can be prevented from entering human cells.
The Pfizer-BioNTech COVID-19 vaccine, an mRNA vaccine, carries the code for the receptor binding domain antigen of the spike protein of Sars Cov-2 virus.
The vaccine consists of modified mRNA that carries the code for the spike protein receptor binding domain antigen roughly surrounded by lipid nanoparticles.
After the vaccine is administered, the vaccinated individual’s own cells produce the receptor binding site antigen of the spike protein of Sars Cov-2 virus.
This antigen is not a virus, just a small part of the virus. Therefore, it does not cause a viral disease.
However, since it is a foreign substance to the human body, both humoral immunity and cellular immunity are formed against this antigen.
Since mRNA itself is recognized as a pathogen by cells, it stimulates strong immunity.
It has been reported that Pfizer-BioNTech COVID-19 vaccine administered as 2 doses prevents Covid-19 infection caused by the original Sars-Cov-2 virus (with no significant mutations) by 95% in individuals aged 16 years and older who have not been infected with Sars-Cov-2 virus before. profdromerdeniz.com
REFERENCES
1-https://www.fda.gov/media/144246/download
2-https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf
3-https://www.nejm.org/doi/full/10.1056/nejmoa2034577