WHAT IS CORONOVAC (SINOVAC) VACCINE?
08/09/2021
Coronavac (Sinovac) is an inactivated virus vaccine.
The virus is replicated in cell cultures and then chemically inactivated.
(Sars-Cov-2 virus produced/replicated in Vero cells is condensed, purified after chemical inactivation with β-propiolactone, and then passed through a series of processes to become an inactivated vaccine.)
This vaccine does not contain an intact virus, it contains many different parts of the virus.
In individuals administered virus fragments with the Coronavac (Sinovac) vaccine, the virus fragments are considered foreign to the body. The body takes action to protect itself against these foreign substances and creates immunity against virus fragments. In this way, immunity against Sars-Cov-2 virus is formed in individuals who have been vaccinated with Coronavac (Sinovac).
In the inactivated vaccine, there are other antigens of the virus as well as spike protein antigens.
Since there is no virus in the inactivated vaccine, it does not cause a viral disease.
After this vaccine is administered, mainly humoral immunity (immunity with antibody production) is formed against the antigens in the vaccine.
There is little or no cellular immunity (absence of antibodies, predominant macrophage and T-cell immunity) against inactivated vaccines.
According to the results of the phase 1/2 clinical study, it was reported that individuals who received the Coronovac vaccine had lower levels of antibody production compared to the antibody levels formed in individuals who had had Covid-19 disease.
The protection of Coronavac against infection with the original Sars-Cov-2 virus (the Sars-Cov-2 virus without significant mutation) was reported between 50.7% and 84%. profdromerdeniz.com
